hERG K+ Channels: Structure, Function, and Clinical Significance
نویسندگان
چکیده
منابع مشابه
hERG K(+) channels: structure, function, and clinical significance.
The human ether-a-go-go related gene (hERG) encodes the pore-forming subunit of the rapid component of the delayed rectifier K(+) channel, Kv11.1, which are expressed in the heart, various brain regions, smooth muscle cells, endocrine cells, and a wide range of tumor cell lines. However, it is the role that Kv11.1 channels play in the heart that has been best characterized, for two main reasons...
متن کاملPlant K+ channels: structure, activity and function.
Introduction In plants as in animals, K+ channel activity is the major determinant of cell membrane conductance [1,2]. Kt channels are therefore involved in central physiological processes such as setting the resting cell membrane potential, transducing signals and shaping action-potential waveforms. In addition, in plant cells, K t channel activity is thought to be involved in long-term fluxes...
متن کاملHERG-like K+ Channels in Microglia
A voltage-gated K+ conductance resembling that of the human ether-à-go-go-related gene product (HERG) was studied using whole-cell voltage-clamp recording, and found to be the predominant conductance at hyperpolarized potentials in a cell line (MLS-9) derived from primary cultures of rat microglia. Its behavior differed markedly from the classical inward rectifier K+ currents described previous...
متن کاملExtracellular K+ is a prerequisite for the function and plasma membrane stability of HERG channels.
RATIONALE The human ether-a-go-go-related gene (HERG) encodes the pore-forming subunits of the rapidly activating delayed rectifier potassium channel (I(Kr)) that is important for cardiac repolarization. Dysfunction of HERG causes long QT syndrome (LQTS) which can lead to sudden cardiac death. We previously showed that a reduction in extracellular K(+) concentration ([K(+)](o)) prolongs QT inte...
متن کاملIdiosyncratic Gating of HERG-like K 1 Channels in Microglia
A simple kinetic model is presented to explain the gating of a HERG-like voltage-gated K 1 conductance described in the accompanying paper (Zhou, W., F.S. Cayabyab, P.S. Pennefather, L.C. Schlichter, and T.E. DeCoursey. 1998. J. Gen. Physiol . 111:781–794). The model proposes two kinetically distinct closing pathways, a rapid one favored by depolarization (deactivation) and a slow one favored b...
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ژورنال
عنوان ژورنال: Physiological Reviews
سال: 2012
ISSN: 0031-9333,1522-1210
DOI: 10.1152/physrev.00036.2011